Sphincter of oddi dysfunction induced by ketamine: A case report.
Nava Raj Sharma, Arjun Basnet, Saral Lamichhane, Kripa Tiwari, Jeffy Varghese, Sudarshan Gautam, Madalasa Pokhrel
Clinical case reports June 1, 2024 DOI: 10.1002/ccr3.9016 via PubMed
Summary
AI-generated from the abstractChronic ketamine use can cause sphincter of Oddi dysfunction (SOD), leading to hepatobiliary complications such as cholestasis, biliary sepsis, and even death. A case of a 29-year-old woman with upper abdominal pain from SOD due to chronic ketamine abuse is presented. Ketamine induces SOD by activating muscarinic receptors in the sphincter of Oddi, obstructing or impairing bile and pancreatic ducts. Taking a detailed substance abuse history is crucial for early identification of ketamine-induced SOD. Early treatment can prevent permanent liver and pancreas damage.
Study at a glance
| Characteristics | Case study Case report Peer reviewed |
|---|---|
| Sample size | 1 |
| Population | 29-year-old female with upper abdominal pain due to sphincter of Oddi dysfunction from chronic ketamine use |
| Keywords | Biliary diseases Drug abuse Low‐dose ketamine Ketamine effects Digestive disorders |
| Citations | 4 |
| Key finding | Chronic ketamine use can induce sphincter of Oddi dysfunction via muscarinic receptor activation, and early identification through substance abuse history can prevent irreversible liver and pancreas damage. |
Abstract
Chronic ketamine use can lead to sphincter of oddi dysfunction (SOD), causing various hepatobiliary complications. Recognizing substance abuse history is vital for early detection. Timely intervention can prevent irreversible liver and pancreas damage. Ketamine is commonly abused as a recreational drug worldwide due to its ability to induce euphoria-like effects. Ketamine abuse is associated with many hepatobiliary side effects ranging from cholestasis to biliary sepsis and death. Here we present a case of a young 29-year female with upper abdominal pain due to SOD resulting from chronic use of ketamine. SOD can result in obstruction or dysfunction of the bile and pancreatic ducts. Ketamine induces SOD by activation of the muscarinic receptors in the sphincter of oddi. Detail history of substance abuse is crucial for early identification of ketamine-induced SOD. Early identification and treatment of this rare condition can prevent permanent injury to the liver and pancreas.