Polish standard of treatment with racemic ketamine for patients with depressive disorders developed by a Working Group appointed by the National Consultant in the field of psychiatry.
Piotr Gałecki, Katarzyna Maria Bliźniewska-Kowalska, Wiesław Jerzy Cubała, Anna Depukat, Anna Mosiołek, Janusz Rybakowski, Jerzy Samochowiec, Bogusław Sobolewski, Agata Szulc, Dominika Dudek
Psychiatria polska June 30, 2024 DOI: 10.12740/PP/189494 via PubMed
Summary
AI-generated from the abstractA Polish expert panel developed national treatment standards for intravenous racemic ketamine in depressive disorders, addressing the one-third of depressed patients who do not respond to standard antidepressants. The guidelines summarize research on ketamine's efficacy and safety for unipolar and bipolar depression, leveraging its action as an NMDA receptor antagonist to modulate the overactive glutamatergic system implicated in depression. The recommendations cover indications, contraindications, precautions, and treatment protocols, aiming to expand therapeutic options for practicing psychiatrists.
Study at a glance
| Characteristics | Review Peer reviewed |
|---|---|
| Intervention | racemic ketamine |
| Topics | Depression Ketamine |
| Keywords | Bipolar disorder Depressive disorders Depression treatment Ketamine therapy |
| Citations | 5 |
| Key finding | The paper presents clinical recommendations for intravenous racemic ketamine as a treatment for depressive symptoms in unipolar and bipolar affective disorder. |
Abstract
The Polish standard of treatment with racemic ketamine for patients with depressive disorders was developed by a Working Group appointed by the National Consultant in the field of psychiatry. Despite the wide range of available medications, as many as one-third of depressed patients do not respond to standard antidepressant treatment, raising the need for an ongoing search for new effective and safe therapies. In recent years, the possible role of overactivity of the glutamatergic system in the etiopathogenesis of depression has again attracted the attention of many experts. The possibility of using substances with a modulating effect on the glutamatergic system in the treatment of depressive disorders has been postulated, among others, the long-known anesthetic ketamine, which is a noncompetitive NMDA receptor antagonist. This paper summarizes the results of studies on the efficacy and safety of racemic ketamine (administered intravenously) in the treatment of patients with depressive symptoms in the course of both unipolar and bipolar affective disorder, and, meeting the expectations of many practicing psychiatrists wishing to broaden the range of therapies offered to their patients, presents recommendations on indications, contraindications, precautions and the treatment regimen itself with intravenous ketamine for patients with mood disorders.