Examining the Combined Use of Psychedelics and Psychiatric Drugs
August 30, 2024 DOI: 10.64239/pi-vl8204
Summary
AI-generated from the abstractSelective serotonin reuptake inhibitors (SSRIs) may not block the subjective or therapeutic effects of psychedelics, but more research is needed. MDMA's effects are completely blocked by SSRIs and SNRIs. Ibogaine has strong QT prolonging effects and should not be combined with other QT prolonging drugs. Ayahuasca contains an MAOI and may cause serotonin syndrome if combined with antidepressants. Combining lithium with psychedelics may increase seizure risk.
Study at a glance
| Characteristics | Review |
|---|---|
| Key finding | SSRIs may not block the effects of psychedelics, but MDMA is completely blocked by SSRIs and SNRIs, and combining certain psychedelics with antidepressants can cause serious adverse effects. |
Abstract
SSRIs may not block the subjective or therapeutic effects of psychedelics, but more research is needed. MDMA is completely blocked by SSRIs and SNRIs, while ibogaine has strong QT prolonging effects and should not be combined with other QT prolonging drugs. Ayahuasca contains an MAOI and may cause serotonin syndrome if combined with antidepressants. Lithium and psychedelics may increase seizure risk.