Lysergic acid diethylamide is a partial agonist at 5-HT2 receptors in ovine uterine artery of late pregnancy
European Journal of Pharmacology January 5, 1993 DOI: 10.1016/0014-2999(93)90420-m via Elsevier
Summary
AI-generated from the abstractLSD caused dose-dependent contractions in isolated sheep uterine arteries from late pregnancy, with half-maximal effect at about 18 nM. The maximum contraction was about half that produced by serotonin. LSD also blocked serotonin-induced contractions. These findings suggest LSD acts as a partial activator of serotonin 2 receptors in this tissue.
Study at a glance
| Characteristics | In vitro experimental study Peer reviewed |
|---|---|
| Population | Isolated ovine uterine artery from late pregnancy |
| Intervention | LSD |
| Citations | 7 |
| Key finding | LSD is a partial agonist at 5-HT2 receptors in ovine uterine artery. |
Abstract
d-Lysergic acid diethylamide (LSD) produced dose-dependent contractions (EC50, 17.9 +/- 2.1 nM) on isolated ovine uterine artery of late pregnancy, which were competitively antagonized by ketanserin. The maximal contraction to LSD was 51% of the 5-HT response. LSD competitively antagonized (pA2 9.21) contractions produced to 5-hydroxytryptamine (5-HT). The results indicate that LSD is a partial agonist at 5-HT2 receptors in ovine uterine artery.