Single ketamine infusion with behavioral therapy improves outcomes in cocaine‐dependent patients
The Brown University Psychopharmacology Update October 1, 2019 DOI: 10.1002/pu.30484
Summary
AI-generated from the abstractA five-week trial with 55 participants found that a single infusion of ketamine combined with mindfulness-based psychotherapy was more effective than midazolam combined with therapy at reducing craving and maintaining abstinence in people with cocaine dependence. Those who received ketamine were 53% less likely to drop out of treatment or use cocaine compared to the midazolam group.
Study at a glance
| Characteristics | Randomized controlled trial Peer reviewed |
|---|---|
| Sample size | 55 |
| Population | Individuals with cocaine dependence |
| Intervention | Ketamine |
| Dose | single infusion |
| Duration | 5-week trial |
| Citations | 2 |
| Key finding | A single infusion of ketamine combined with mindfulness-based psychotherapy was more effective than midazolam with therapy in limiting craving and maintaining abstinence among individuals with cocaine dependence. |
Abstract
A five‐week trial involving 55 participants has concluded that a single infusion of ketamine in combination with a course of mindfulness‐based psychotherapy was more effective than midazolam with therapy in limiting craving and maintaining abstinence among individuals with cocaine dependence. The researchers found that participants receiving ketamine were 53% less likely to drop out of treatment or use cocaine in comparison with the midazolam group.