Distortions of Vision and Pain: Two Functional Facets of D-Lysergic Acid Diethylamide

LSD produces visual distortions and analgesia. Visual effects likely stem from reduced light-evoked input to the dorsal lateral geniculate nucleus from retinal pathways, especially affecting slower or complex-receptive-field afferents. LSD's analgesic effect, accompanied by severe psychotic symptoms, appears to result from actions on a centrifugally controlled pain system involving midbrain raphe neurons.

Study at a glance

Abstract

D-lysergic acid diethylamide (LSD) produces distortions of visual perception and analgesia. Evidence is advanced from a functional standpoint that the observed visual effects result from an attenuation of light-evoked input to the dorsal lateral geniculate nucleus (LGN) from the purely centripetal pathways of the retina. More slowly responding visual afferents or those with more complex receptive fields seem to be affected most. LSD analgesia, accompanied by severe psychotic symptoms, appears to result from drug actions on a centrifugally controlled pain system involving neurons of the midbrain raphe.