ChemInform Abstract: Observations Concerning the Synthesis of Tryptamine Homologues and Branched Tryptamine Derivatives via the Borrowing Hydrogen Process: Synthesis of Psilocin, Bufotenin, and Serotonin.

A new chemical method for selective indole alkylation uses iridium catalysis and a borrowing hydrogen strategy with amino alcohols as nitrogen-containing electrophiles. The reaction produces alkylated indole products, offering a synthetic route that avoids pre-functionalized starting materials.

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Abstract

AbstractThe selective indole alkylation reaction applying the Ir‐catalyzed‐borrowing hydrogen methodology and using amino alcohols (II), (V), (VII) as suitable nitrogen‐containing electrophiles is reported.