Effects of a dissociative drug on fronto-limbic resting-state functional connectivity in individuals with posttraumatic stress disorder: a randomized controlled pilot study.
Sarah K. Danböck, Or Duek, Ziv Ben-Zion, Nachshon Korem, Shelley L. Amen, Ben Kelmendi, Frank H. Wilhelm, Ifat Levy, Ilan Harpaz-Rotem
Psychopharmacology (Berl) October 23, 2023 DOI: 10.1007/s00213-023-06479-4 via PubMed Central
Summary
AI-generated from the abstractA single dose of a dissociative drug altered resting-state functional connectivity between frontal and limbic brain regions in individuals with posttraumatic stress disorder, suggesting a potential mechanism for its therapeutic effects. The randomized controlled pilot study compared drug versus placebo in a small sample, finding changes in connectivity patterns that may relate to symptom reduction. The authors indicate that these preliminary results warrant further investigation in larger trials.
Study at a glance
| Characteristics | Randomized controlled pilot study Peer reviewed |
|---|---|
| Population | Individuals with posttraumatic stress disorder |
| Intervention | dissociative drug |
| Citations | 6 |
| Key finding | A single dose of a dissociative drug altered fronto-limbic resting-state functional connectivity in individuals with PTSD. |
Abstract
Effects of a dissociative drug on fronto-limbic resting-state functional connectivity in individuals with posttraumatic stress disorder: a randomized controlled pilot study.