NOVEL STRUCTURAL HYBRIDS OF MESCALINE WITH PCP-ANALOGS: POTENTIAL ANTAGONISTS FOR CENTRAL PCP-RECEPTORS

Researchers designed new chemical compounds that combine features of mescaline and phencyclidine (PCP) to explore their potential interaction with PCP receptors in rat brains. The proposed molecules are structural hybrids, including variants with an N-(2-chloroethyl) group that could allow them to bind permanently to receptors. However, the actual effects of mescaline and the potential blocking activity of these new compounds at central PCP receptors have not yet been tested.

Study at a glance

Abstract

The possible involvement of the synclinal conformation of mescaline with phencyclidine (PCP)-receptors has promoted the synthesis of certain novel structural hybrids of mescaline with PCP-analogs. The effect of mescaline and the potential antagonisticactivity of the newly proposed derivatives at central PCP-receptors of albino rat brains will await investigation. The suggested compounds were chemically 1-aryl-1-(3,4,5-trimethoxy; or trihydroxy) phenethylamino; or N-substituted-phenethylamino cycloalkanes. An N-(2-chloroethyl) moiety was, also incorporated into some of the designed analogs for exploration of the possible participation of such alkylating arm to the elicited activity.