Ketamine treatment for individuals with treatment-resistant depression: longitudinal qualitative interview study of patient experiences

Twelve fee-paying patients with treatment-resistant depression (ages 21–70, six women and six men, most reporting suicidality and some reporting self-harm) were interviewed before, during, and months after starting ketamine treatment in a routine clinic. Nearly all experienced mood improvement after initial treatments, ranging from negligible to dramatic, and eight reported reduced suicidality. Improvements were generally transitory; two patients had sustained consistent benefit and two had sustained but limited improvement. Some described hopelessness when treatment stopped working, and three experienced increased suicidal ideation. Side-effects were common and significant for two patients. Treatment cost and lack of longer-term benefit were problematic. Suggestions included closer monitoring and adjunctive therapy.

Study at a glance

Abstract

BackgroundKetamine has recently received considerable attention regarding its antidepressant and anti-suicidal effects. Trials have generally focused on short-term effects of single intravenous infusions. Research on patient experiences is lacking.AimsTo investigate the experiences over time of individuals receiving ketamine treatment in a routine clinic, including impacts on mood and suicidality.MethodTwelve fee-paying patients with treatment-resistant depression (6 females, 6 males, age 21–70 years; 11 reporting suicidality and 6 reporting self-harm) who were assessed as eligible for ketamine treatment participated in up to three semi-structured interviews: before treatment started, a few weeks into treatment and ≥2 months later. Data were analysed thematically.ResultsMost participants hoped that ketamine would provide respite from their depression. Nearly all experienced improvement in mood following initial treatments, ranging from negligible to dramatic, and eight reported a reduction in suicidality. Improvements were transitory for most participants, although two experienced sustained consistent benefit and two had sustained but limited improvement. Some participants described hopelessness when treatment stopped working, paralleled by increased suicidal ideation for three participants. The transient nature and cost of treatment were problematic. Eleven participants experienced side-effects, which were significant for two participants. Suggestions for improving treatment included closer monitoring and adjunctive psychological therapy.ConclusionsKetamine treatment was generally experienced as effective in improving mood and reducing suicidal ideation in the short term, but the lack of longer-term benefit was challenging for participants, as was treatment cost. Informed consent procedures should refer to the possibilities of relapse and associated increased hopelessness and suicidality.