Ketamine treatment alleviates suicide ideation in high-risk populations: a systematic review and meta-analysis
Wen Tang, Wei-Wei Jiang, Wen-Qian Que, Wan-Qing Zhang, Hong-Lin Chen, Li-Juan Zhou
Epidemiology and Psychiatric Sciences January 1, 2026 DOI: 10.1017/s2045796025100371 via OpenAlex
Summary
AI-generated from the abstractKetamine treatment significantly reduces suicide ideation in high-risk individuals, with a large effect size of -1.40 based on a meta-analysis of 21 studies involving 927 participants. The effect is more pronounced in younger individuals and those with severe ideation. Common adverse events include dissociation (38.8%), nausea (31.6%), dizziness (24.7%), headache (22.0%), and anxiety (15.8%). The evidence is rated low quality, and further research is needed to determine optimal dosing and long-term effects.
Study at a glance
| Characteristics | Systematic review and meta-analysis Randomized Double-blind Open-label Peer reviewed |
|---|---|
| Sample size | 927 |
| Population | High-risk individuals with suicide ideation |
| Intervention | Ketamine |
| Topics | Ketamine |
| Keywords | Dosing Suicidal ideation Medline Suicide prevention |
| Key finding | Ketamine treatment produces a large and clinically meaningful reduction in suicide ideation, especially in younger individuals and those with severe ideation. |
Abstract
Abstract Aims To synthesize the available experimental study evidence to estimate the effects of ketamine on suicide ideation (SI) in high-risk individuals. Methods We conducted a systematic review and meta-analysis following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Double-blind randomized controlled trials and open-label studies investigating the safety and effectiveness of ketamine on SI published up to October 2025 were identified. Data were pooled using random-effects meta-analysis. The main outcome was standardized mean difference on SI in high-risk individuals. Secondary outcomes were the percentage of adverse events and the moderator effects. Results We identified 21 studies with a total of 927 participants meeting our inclusion criteria. The pooled effect size for the reduction of SI after ketamine treatment was significant and clinically meaningful (large effect size of −1.40, 95% confidence interval: −2.15 to −0.66, P < 0.001, low–quality evidence). Dissociation (38.8%, P = 0.014), nausea (31.6%, P < 0.001), dizziness (24.7%, P = 0.003), headache (22.0%, P = 0.011) and anxiety (15.8%, P < 0.001) were the frequently reported adverse events. Moderator analyses indicated that the effect was higher in younger individuals and those with severe SI. Conclusions Our findings highlight the effectiveness of ketamine in reducing SI in high-risk individuals, especially younger individuals and those with severe ideation. Nonetheless, additional research is required to better understand optimal dosing regimens and the potential long-term effects of ketamine treatment.