Ketamine for Depression—Knowns, Unknowns, Possibilities, Barriers, and Opportunities

Ketamine, an anesthetic with a history of recreational use, is being investigated for new on- and off-label indications across medical disciplines, including treatment-resistant depression, chronic pain, and other conditions. The article discusses the expanding experimental and clinical applications of ketamine, highlighting its potential benefits and risks as research progresses.

Study at a glance

Abstract

This Viewpoint discusses ketamine and its new and experimentally investigated on- and off-label indications that span different medical disciplines.