Dissociative Effects and Response to Ketamine in Youth With Treatment-Resistant Depression
September 19, 2023 DOI: 10.64239/pi-capst1504
Summary
AI-generated from the abstractKetamine's dissociative symptoms do not predict treatment response in adolescents. Among adolescents given midazolam, higher depersonalization symptoms within 24 hours were linked to less improvement in depression. Tricyclic antidepressants work better in adults than in children and adolescents.
Study at a glance
| Characteristics | Observational cohort |
|---|---|
| Population | Adolescents |
| Interventions | Ketamine Midazolam Tricyclic antidepressants |
| Duration | 24 hours |
| Key finding | No association was found between ketamine's dissociative symptoms and treatment response in adolescents. |
Abstract
No association was found between ketamine's dissociative symptoms and treatment response in adolescents. Adolescents receiving midazolam showed less depression improvement with higher depersonalization symptoms in 24 hours. Tricyclic antidepressants are more effective in adults than in children and adolescents.