Ketamine for Adolescent Depression
February 28, 2023 DOI: 10.64239/pi-capst0804
Summary
AI-generated from the abstractKetamine therapies can rapidly relieve depression and reduce suicidal thoughts, making them especially promising for adolescents with treatment-resistant depression. In one randomized, double-blind study of adolescents with severe major depression, ketamine produced a strong effect size in reducing depressive symptoms 24 hours after infusion. However, there are currently very few studies investigating ketamine use in treatment-resistant adolescents with depression.
Study at a glance
| Characteristics | Randomized controlled trial Double-blind |
|---|---|
| Population | Adolescents with severe major depression |
| Intervention | Ketamine |
| Duration | 24 hours after infusion |
| Key finding | Ketamine had a strong effect size for reducing depressive symptoms 24 hours after infusion in adolescents with severe major depression. |
Abstract
Ketamine therapies can offer rapid relief of depression and an antisuicidal effect, making them of particular interest for adolescents with treatment-resistant depression. In 1 randomized, double-blind study of adolescents with severe major depression, ketamine had a strong effect size for reducing depressive symptoms 24 hours after infusion. Currently, there is minimal investigation and few studies on the use of ketamine in treatment-resistant adolescents with depression.