Shorter to be effective: subanesthetic-dose ketamine infusion reduces the global and regional path length of brain functional connectivity in patients with treatment-resistant depression and suicidal ideation.
Wei-Chen Lin, Li-Kai Cheng, Tung-Ping Su, Li-Fen Chen, Pei-Chi Tu, Cheng-Ta Li, Ya-Mei Bai, Shih-Jen Tsai, Mu-Hong Chen
Psychopharmacology (Berl) May 22, 2026 DOI: 10.1007/s00213-026-07089-6 via PubMed
Summary
AI-generated from the abstractA single subanesthetic-dose ketamine infusion shortens the global and regional path length of brain functional connectivity in people with treatment-resistant depression and suicidal ideation, suggesting a more efficient network organization. This change in connectivity may underlie the rapid antidepressant and anti-suicidal effects of ketamine.
Study at a glance
| Characteristics | Preprint Peer reviewed |
|---|---|
| Population | Patients with treatment-resistant depression and suicidal ideation |
| Intervention | subanesthetic-dose ketamine infusion |
| Dose | subanesthetic-dose |
| Key finding | Subanesthetic-dose ketamine infusion reduces the global and regional path length of brain functional connectivity in patients with treatment-resistant depression and suicidal ideation. |
Abstract
Shorter to be effective: subanesthetic-dose ketamine infusion reduces the global and regional path length of brain functional connectivity in patients with treatment-resistant depression and suicidal ideation.