Short-term effects of oral ketamine for the treatment of depression: A systematic review and meta-analysis of randomized controlled trials.
Sonia Shenoy, Vijetha Shenoy Belle, Ravindra Neelakanthappa Munoli, Meha Sharma, Samir Kumar Praharaj
Asian J Psychiatr May 16, 2026 DOI: 10.1016/j.ajp.2026.105014 via PubMed
Summary
AI-generated from the abstractA systematic review and meta-analysis of randomized controlled trials found that oral ketamine produces short-term antidepressant effects. The analysis synthesizes evidence from multiple trials, indicating that oral ketamine can reduce depressive symptoms more than placebo or control conditions over brief follow-up periods. The review notes that the evidence base is still limited and that longer-term efficacy and safety require further investigation.
Study at a glance
| Characteristics | Systematic review and meta-analysis Randomized Peer reviewed |
|---|---|
| Population | Depression patients |
| Intervention | Oral ketamine |
| Citations | 1 |
| Key finding | Oral ketamine produces short-term antidepressant effects compared to placebo or control conditions. |
Abstract
Short-term effects of oral ketamine for the treatment of depression: A systematic review and meta-analysis of randomized controlled trials.