Sustained Effects of Low-to-Moderate Doses of Psilocybin on Brain Connectivity
Chiranth Bhagavan, Orwa Dandash, Olivia Carter, Alexander Bryson, Richard A. Kanaan
medRxiv Preprint Server April 17, 2026 preprint DOI: 10.64898/2026.04.17.26351147 via medRxiv
Summary
AI-generated from the abstractPsilocybin, a classic psychedelic, acutely alters brain functional connectivity, and these changes are linked to therapeutic doses and subjective effects. Some evidence indicates that such changes persist beyond the acute drug administration period. However, the effects of lower doses on sustained connectivity changes remain unclear.
Study at a glance
| Characteristics | Review |
|---|---|
| Population | Participants receiving low-to-moderate psilocybin doses |
| Key finding | The effects of lower doses of psilocybin on sustained brain connectivity changes remain unclear. |
Abstract
Background Psilocybin is a classic psychedelic that acutely alters brain functional connectivity. These changes are linked to therapeutic doses and subjective effects, with some evidence that changes persist beyond acute drug administration. However, the effects of lower doses on sustained connectivity changes remain unclear.