Reshaping human neurons.
Jessica L Maltman, Javier González-Maeso
eLife March 31, 2026 DOI: 10.7554/elife.110981 via PubMed
Summary
AI-generated from the abstractExposure to psilocin, the active metabolite of the psychedelic psilocybin, increases structural complexity and strengthens synaptic connections in human neurons derived from stem cells. These changes suggest enhanced neuroplasticity at the cellular level.
Study at a glance
| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Human induced pluripotent stem cell derived cortical neurons |
| Intervention | Psilocin |
| Topics | Neuroplasticity Psilocybin Serotonin |
| Keywords | Bdnf Human Neuroscience |
| Key finding | Psilocin increases structural complexity and strengthens synaptic connections in human induced pluripotent stem cell derived cortical neurons. |
Abstract
Human neurons derived from stem cells show increased structural complexity and stronger synaptic connections after exposure to psilocin, the active metabolite of the psychedelic psilocybin.