Esketamine reduces postoperative depression in breast cancer through TREK-1 channel inhibition and neurotransmitter modulation.
Jiachi Xu, Mingcan Li, Yu Hu, Qin Yang, Qiang Long, Hui Zhou
Cancer cell international February 18, 2025 DOI: 10.1186/s12935-025-03664-7 via PubMed
Summary
AI-generated from the abstractPostoperative depression reduces quality of life in breast cancer patients. Esketamine alleviates depressive symptoms by inhibiting TREK-1 potassium channel protein expression, which enhances GABA neurotransmitter release and improves hippocampal neuron activity. In vitro overexpression of TREK-1 reversed these effects. Analysis of data from 54 female breast cancer patients who had surgery between 2019 and 2023, divided into experimental and control groups based on esketamine treatment, along with transcriptomic sequencing of rat hippocampal neurons, identified potassium ion-related pathways and TREK-1 as a key regulatory gene. Esketamine's inhibition of TREK-1 channels and promotion of hippocampal neuron activity suggest a novel therapeutic strategy for postoperative depression in breast cancer patients.
Study at a glance
| Characteristics | Controlled trial with experimental and control groups, plus in vitro and transcriptomic analyses Peer reviewed |
|---|---|
| Sample size | 54 |
| Population | Female breast cancer patients who underwent surgery |
| Intervention | Esketamine |
| Topics | Esketamine |
| Keywords | Breast cancer Hippocampal neurons Postoperative depression Trek-1 channels #postoperativecare post-surgery care |
| Citations | 6 |
| Key finding | Esketamine alleviates postoperative depression in breast cancer patients by inhibiting TREK-1 channels and promoting hippocampal neuron activity. |
Abstract
Postoperative depression significantly affects the quality of life of breast cancer patients. This study explores the potential therapeutic effects of esketamine on postoperative depression through modulation of the TREK-1 two-pore domain potassium channel. We analyzed data from 54 female breast cancer patients who underwent surgery at our hospital between 2019 and 2023, dividing them into experimental and control groups based on esketamine treatment. Transcriptomic sequencing of hippocampal neurons from rats identified potassium ion-related pathways and key regulatory genes, including TREK-1, influenced by esketamine. In vitro studies showed that esketamine primarily alleviates depressive symptoms by inhibiting TREK-1 protein expression, enhancing GABA neurotransmitter release, and improving neuronal activity, while overexpression of TREK-1 reversed these effects. Esketamine's inhibition of TREK-1 channels and promotion of hippocampal neuron activity effectively alleviate postoperative depression in breast cancer patients, suggesting a novel therapeutic strategy.