Catatonia Associated With First-Time Psilocybin Exposure: A Case Report
Jasbir Singh, Pranathi Mruthyunjaya
Cureus April 5, 2026 DOI: 10.7759/cureus.106474 via OpenAlex
Summary
AI-generated from the abstractA 28-year-old man with no prior psychiatric or substance use history developed catatonia—specifically mutism and inability to feed himself—for six months after his first use of psilocybin. Imaging and lab tests showed no abnormalities. This case is one of the earliest documented instances of catatonia triggered by psilocybin.
Study at a glance
| Characteristics | Case report Peer reviewed |
|---|---|
| Sample size | 1 |
| Population | A 28-year-old male patient |
| Intervention | Psilocybin |
| Duration | Six months |
| Citations | 1 |
| Key finding | Psilocybin ingestion can induce catatonia in individuals without prior psychiatric or substance use history. |
Abstract
In this case report, we highlight a 28-year-old male patient with predominantly retarded type of catatonia following a single incidence of psilocybin ingestion. This patient presented with a history of six months of mutism and inability to feed himself after consuming psilocybin for the first time. He did not have any history of psychiatric illness or substance use. Imaging and laboratory results were unremarkable. The goal of this case report is to document one of the earliest records of psilocybin-induced catatonia.