Pharmacology of Lysergic Acid Diethylamide and Some of Its Related CompoundS
Journal of Pharmacy and Pharmacology September 1, 1957 DOI: 10.1111/j.2042-7158.1957.tb12312.x via OpenAlex
Summary
AI-generated from the abstractLysergic acid diethylamide (LSD) and related compounds produce profound psychological effects by interacting with serotonin receptors in the brain. The paper describes the pharmacology of LSD, including its chemical structure, absorption, distribution, and metabolism. It discusses how small changes to the LSD molecule can greatly alter its potency and psychological effects. The authors note that LSD acts as a serotonin antagonist in some tissues but produces effects similar to serotonin excess in the central nervous system. The review covers the history of LSD's discovery, its effects on animals and humans, and its potential therapeutic applications in psychiatry.
Study at a glance
| Characteristics | Review Peer reviewed |
|---|---|
| Topics | LSD |
| Keywords | Pharmacy Clinical pharmacology Internal medicine Family medicine |
| Citations | 64 |
| Key finding | LSD and its analogues produce their psychological effects primarily through interaction with serotonin receptors, with minor structural changes dramatically altering potency and effect. |
Abstract
Journal Article Pharmacology of Lysergic Acid Diethylamide and Some of Its Related CompoundS Get access E Rothlin E Rothlin Professor of the University of Basle, Sonnenweg 6, Basle Search for other works by this author on: Oxford Academic Google Scholar Journal of Pharmacy and Pharmacology, Volume 9, Issue 1, September 1957, Pages 569–587, https://doi.org/10.1111/j.2042-7158.1957.tb12312.x Published: 12 April 2011