Lysergic Acid Diethylamide: Radioimmunoassay
Alison Taunton-Rigby, S. Sher, Paul R. Kelley
Science July 13, 1973 DOI: 10.1126/science.181.4095.165 via OpenAlex
Summary
AI-generated from the abstractA radioimmunoassay can detect picogram amounts of LSD in human urine. Antibodies against LSD were produced by immunizing rabbits with a conjugate of LSD and human serum albumin. The specificity of these antibodies was confirmed through competitive binding studies. This method enables the measurement of extremely small quantities of the drug.
Study at a glance
| Characteristics | Laboratory method development Peer reviewed |
|---|---|
| Topics | LSD Serotonin |
| Keywords | Radioimmunoassay Conjugate Antibody Human serum albumin |
| Citations | 50 |
| Key finding | A radioimmunoassay using antibodies raised against an LSD-human serum albumin conjugate can detect picogram amounts of LSD in human urine. |
Abstract
A radioimmnunoassay for d-lysergic acid diethylamide (LSD) is described. Antibodies to LSD were obtained by immunizing rabbits with a conjugate of LSD and human serum albumin. The specificity of the antibody was shown by competitive binding studies. The method has been used to detect the presence of LSD in human urines. Picogram amounts can be measured by this assay.