Effects of Intraoperative Esketamine–Dexmedetomidine Combination on Postpartum Depressive Symptoms and Neuropsychiatric Events Following Cesarean Delivery: A Randomized Controlled Trial
Meng-Meng Li, Qingfeng Wei, Qian-Yun Zhu, Xin Qing, Xuesheng Liu, Pan-Pan Fang
Drug Design Development and Therapy March 1, 2026 DOI: 10.2147/dddt.s587487 via OpenAlex
Summary
AI-generated from the abstractCombining low-dose dexmedetomidine with esketamine during cesarean section improves early postpartum depressive symptoms, reduces neuropsychiatric side effects during surgery, and increases maternal satisfaction, while remaining safe for both mother and newborn.
Study at a glance
| Characteristics | Randomized controlled trial Peer reviewed |
|---|---|
| Population | Women undergoing cesarean section |
| Interventions | low-dose dexmedetomidine esketamine |
| Topics | Depression |
| Keywords | Dexmedetomidine Adverse effect Randomized controlled trial Postpartum depression Incidence geometry |
| Key finding | Combined low-dose dexmedetomidine and esketamine during cesarean section provides short-term improvement in early postpartum depressive symptoms. |
Abstract
Combined low-dose dexmedetomidine and esketamine during cesarean section provides a short-term improvement in early postpartum depressive symptoms, reduces intraoperative neuropsychiatric adverse events, and enhances maternal satisfaction, with a favorable maternal and neonatal safety profile.