Effect of intraoperative low-dose esketamine on postoperative quality of recovery in patients undergoing laparotomy for gynecologic malignancy: a randomized controlled trial
Zhi-Yu Geng, Yan Zhang, Hui Bi, Xin Yan, Linlin Song, Hui-Cheng Song
International Journal of Surgery September 23, 2025 DOI: 10.1097/js9.0000000000003501 via OpenAlex
Summary
AI-generated from the abstractAdding a low dose of esketamine during surgery did not improve recovery quality, measured by the QoR-40 score, for patients undergoing laparotomy for gynecologic malignancy as part of a multimodal pain management plan. The result suggests no additional benefit from this intervention. More research is needed to determine whether different doses or patient groups might benefit.
Study at a glance
| Characteristics | Randomized controlled trial Peer reviewed |
|---|---|
| Population | Patients undergoing gynecologic malignancy laparotomy |
| Intervention | Esketamine |
| Dose | low-dose |
| Topics | Ketamine |
| Keywords | Medicine Laparotomy Randomized controlled trial Anesthesia Surgery |
| Citations | 1 |
| Key finding | Intraoperative low-dose esketamine failed to further improve the QoR-40 score after gynecologic malignancy laparotomy when used as part of a multimodal analgesic regimen. |
Abstract
Intraoperative low-dose esketamine failed to further improve the QoR-40 score after gynecologic malignancy laparotomy when used as part of a multimodal analgesic regimen. Further research is needed to explore the optimal dosage and indications of esketamine in this patient population.