Ketamine Reduces Suicidality-Associated Emergency Department Utilization in Patients With Treatment-Resistant Depression
Liliana Patarroyo-Rodriguez, Vanessa K. Pazdernik, Jennifer L. Vande Voort, Simon Kung, Mark A. Frye, Balwinder Singh
The Journal of Clinical Psychiatry September 17, 2025 DOI: 10.4088/jcp.25m15941 via OpenAlex
Summary
AI-generated from the abstractKetamine and esketamine reduced long-term emergency department visits for suicidality among individuals with treatment-resistant depression. Further research with longer follow-up is needed to determine whether these benefits depend on mood state or reflect an independent mechanism.
Study at a glance
| Characteristics | Review Peer reviewed |
|---|---|
| Population | Individuals with treatment-resistant depression |
| Interventions | Ketamine Esketamine |
| Citations | 1 |
| Key finding | Ketamine and esketamine reduced long-term ED visits for suicidality in individuals with TRD. |
Abstract
Conclusions: Ketamine and esketamine reduced long-term ED visits for suicidality in individuals with TRD. Further longer-term follow-up research is encouraged to ascertain if these benefits on suicidality reduction are mood state dependent or reflect an independent mechanism.