Comparative Efficacy of Psilocybin and MDMA in PTSD Treatment: A Systematic Review of Long-Term Outcomes

Post-traumatic stress disorder (PTSD) is a major public health problem that current treatments like psychotherapy and standard medications address with limited success. Psychedelics, also called hallucinogens, alter perception, mood, and cognition and are known to influence neuron plasticity and the formation of new neural connections. This review compares the effectiveness of psilocybin and MDMA for treating PTSD.

Study at a glance

Abstract

Highly stressful events can lead to post-traumatic stress disorder (PTSD)-a significant public health concern which existing treatments (e.g., psychotherapy and traditional medications) have shown marginal efficacy for.Psychedelics-alternatively called hallucinogens-are psychoactive substances that cause perception, mood, and cognitive changes.Because they are known for their impact on neuron plasticity and the formation of new connections, researchers are exploring psychedelics' therapeutic potential for PTSD.This review compares psilocybin and MDMA's effectiveness in treating PTSD.