Analytical profile of the lysergamide 1cP-AL-LAD and detection of impurities.
Pierce V Kavanagh, Folker Westphal, Benedikt Pulver, Hannes M Schwelm, Alexander Stratford, Volker Auwärter, Stephen J Chapman, Adam L Halberstadt, Simon D Brandt
Drug testing and analysis March 1, 2023 DOI: 10.1002/dta.3397 via PubMed
Summary
AI-generated from the abstractA new lysergamide, 1cP-AL-LAD, was analyzed using chromatographic, mass spectrometric, and spectroscopic methods. A powdered sample from an online vendor contained 17 impurities, including AL-LAD and 1P-AL-LAD (confirmed by reference standards) and tentatively identified compounds such as 1-acetyl-AL-LAD and oxidation products of the N6-allyl group and ergoline ring. The substance was also found in blotter paper samples sold online for recreational use. These findings provide analytical data for researchers interested in lysergamide chemistry.
Study at a glance
| Characteristics | Analytical study Peer reviewed |
|---|---|
| Population | Powdered sample and blotter samples of 1cP-AL-LAD |
| Topics | LSD |
| Keywords | Impurities New psychoactive substances Psychedelics hallucinogens Entheogens Psychoactive drugs |
| Citations | 7 |
| Key finding | 1cP-AL-LAD contains multiple impurities, including confirmed AL-LAD and 1P-AL-LAD, and is present in recreational blotter samples. |
Abstract
The development of novel lysergamides continues to occur, based on both the needs of psychedelic medicine and commercial interest in new recreational substances. The present study continues the authors' research on novel lysergamides and describes the analytical profile of 1-cyclopropanoyl-AL-LAD (IUPAC name: 1-(cyclopropanecarbonyl)-N,N-diethyl-6-(prop-2-en-1-yl)-9,10-didehydroergoline-8β-carboxamide; 1cP-AL-LAD), using various chromatographic, mass spectrometric, and spectroscopic methods. Analysis of a powdered sample of 1cP-AL-LAD, obtained from an online vendor, by high performance liquid chromatography-electrospray ionization-quadrupole time-of-flight mass spectrometry in full scan/AutoMS/MS mode revealed the detection of 17 impurities based on high-resolution tandem mass spectral data; tentative determination of their identity was based on mass spectral grounds alone, though detection of AL-LAD and 1P-AL-LAD was confirmed using available reference standards. Other tentative compound identifications included 1-acetyl-AL-LAD and several other substances potentially reflecting oxidation of the N6 -allyl group as well as other positions on the ergoline ring system. These data may assist those interested in the chemistry of lysergamides. Finally, 1cP-AL-LAD was also detected in samples of "blotters" sold online for recreational use.