EFFECT OF ZOTEPINE ON HEAD-TWITCH INDUCED BY L-5-HYDROXYTRYPTOPHAN, MESCALINE AND 2,5-DIMETHOXY-4-METHYLAMPHETAMINE IN MICE AND RATS
Tsuneyuki Yamamoto, Naoe Tazoe, Showa Ueki, Kyoichi Shimomura, Hisashi Satoh, Jo Mori
The Japanese Journal of Pharmacology January 1, 1983 DOI: 10.1016/s0021-5198(19)52515-x via OpenAlex
Summary
AI-generated from the abstractZotepine, a new neuroleptic, potently inhibits head-twitch induced by L-5-hydroxytryptophan, mescaline, and 2,5-dimethoxy-4-methylamphetamine in mice and rats, similar to haloperidol and the serotonin receptor blocker cyproheptadine. The results indicate that zotepine has a potent anti-hallucinogenic effect.
Study at a glance
| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Mice and rats |
| Interventions | Zotepine cyproheptadine |
| Topics | Mescaline Serotonin |
| Keywords | Cyproheptadine Pharmacology Chemistry Hallucinogen |
| Citations | 2 |
| Key finding | Zotepine and haloperidol produced potent inhibitory effects on head-twitch induced by L-5HTP, mescaline, and DOM, indicating zotepine has a potent anti-hallucinogenic effect. |
Abstract
The effect of zotepine, a new neuroleptic, on head-twitch induced by L-5-hydroxytryptophan (L-5HTP), mescaline and 2,5-dimethoxy-4-methylamphetamine (DOM) in mice and rats was compared with that of known neuroleptics and the serotonin receptor blocker cyproheptadine. Among the neuroleptics tested, zotepine and halo-peridol produced potent inhibitory effects on head-twitch induced by these three drugs. The results indicate that zotepine has a potent anti-hallucinogenic effect.