A STEREOTYPED RESPONSE INDUCED BY MESCALINE IN MICE AS A MEANS OF INVESTIGATING THE PROPERTIES OF DRUGS ACTING ON THE CNS
Journal of Pharmacy and Pharmacology September 1, 1958 DOI: 10.1111/j.2042-7158.1958.tb10339.x via OpenAlex
Summary
AI-generated from the abstractMescaline induces a stereotyped response in mice, measured as spontaneous activity in special cages. Chlorpromazine most specifically blocks this response. Promazine, hexobarbitone, and pentobarbitone also reduce the effect at doses that do not impair motor function, while phenobarbitone has little effect. Meprobamate, mephenesin, a thiadiazole derivative (L 1458), and azacyclonol do not produce specific antagonistic effects at non-paralyzing doses. Atropine does not significantly influence the response, but morphine enhances it.
Study at a glance
| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Mice |
| Interventions | Promazine Hexobarbitone Pentobarbitone Phenobarbitone Meprobamate Mephenesin L 1458 Azacyclonol Atropine Morphine |
| Topics | Mescaline |
| Keywords | Meprobamate Atropine Chlordiazepoxide Pharmacology |
| Citations | 8 |
| Key finding | Chlorpromazine shows the highest specificity in blocking the stereotyped response induced by mescaline in mice. |
Abstract
Abstract The effects of mescaline on spontaneous activity of mice placed in special cages have been studied. The typical response (stereotyped response) has been recorded and assessed in terms of percentage of animals showing the effect. Among drugs affecting the response chloropromazine shows the highest specificity. Promazine, hexobarbitone and pentobarbitone also show a definite but minor effect in doses that do not impair motor function. The response is little affected by phenobarbitone. Meprobamate, mephenesin and a thiadiazole derivative (L 1458) at non-paralyzing doses, and also azacyclonol, do not produce specific antagonistic effects. Nor is the effect significantly influenced by atropine, but it is enhanced by morphine.