Synthesis of Phenethylamines Related to Mescaline as Possible Psychotomimetic Agents1

Several new phenethylamine compounds structurally related to mescaline were synthesized and tested for psychotomimetic activity in animals. The synthesis involved introducing sulfur and phosphorus substituents into the phenethylamine backbone. Some of the new compounds produced behavioral effects in animals similar to those of mescaline, suggesting they may act as hallucinogens. The work aimed to explore how chemical modifications to the mescaline structure affect psychoactive potency.

Study at a glance

Abstract

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of Phenethylamines Related to Mescaline as Possible Psychotomimetic Agents1Orrie M. Friedman, K. N. Parameswaran, and Sumner BursteinCite this: J. Med. Chem. 1963, 6, 3, 227–229Publication Date (Print):May 1, 1963Publication History Published online1 May 2002Published inissue 1 May 1963https://pubs.acs.org/doi/10.1021/jm00339a002https://doi.org/10.1021/jm00339a002research-articleACS PublicationsRequest reuse permissionsArticle Views302Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts