Mescaline-induced changes of brain-cortex ribosomes. Effect of mescaline on the hydrogen-bonded structure of ribonucleic acid of brain-cortex ribosomes
Biochemical Journal May 1, 1970 DOI: 10.1042/bj1170969 via OpenAlex
Summary
AI-generated from the abstractMescaline sulfate reduces the hydrogen-bonded structure of ribosomal RNA in goat brain-cortex slices. The hyperchromic effect of heating and formaldehyde reaction showed that ribosomal total RNA from treated slices had a smaller proportion of hydrogen-bonded structure than RNA from untreated slices. Mescaline also appeared to lower the hydrogen-bonded structure specifically in ribosomal 28S RNA of brain-cortex tissue.
Study at a glance
| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Goat brain-cortex slices |
| Intervention | mescaline sulphate |
| Topics | Mescaline |
| Keywords | Ribosome Ribosomal rna Cortex anatomy Brain cortex |
| Citations | 8 |
| Key finding | Mescaline sulfate reduces the hydrogen-bonded structure of ribosomal RNA, including 28S RNA, in goat brain-cortex slices. |
Abstract
1. The action of mescaline sulphate on the hydrogen-bonded structure of the RNA constituent of ribosomes of goat brain-cortex slices was studied by using the hyperchromic effect of heating and formaldehyde reaction. 2. The ribosomal total RNA species of the mescaline-treated brain-cortex slices have a smaller proportion of hydrogen-bonded structure than the ribosomal RNA species of the untreated brain-cortex slices. 3. Mescaline also appears to have affected this lowering of hydrogen-bonded structure of the ribosomal 28S RNA of brain-cortex tissue.