3,4,5-Trimethoxybenzoic acid, a new mescaline metabolite in humans.
L. Demisch, Peter Kaczmarczyk, Nikolaus Seiler
Drug Metabolism and Disposition September 1, 1978 DOI: 10.1016/s0090-9556(25)06273-7 via OpenAlex
Summary
AI-generated from the abstractAfter people took 400 mg of mescaline sulfate, a metabolite called 3,4,5-trimethoxybenzoic acid was found in their urine and identified using gas chromatography-mass spectrometry. This substance appeared in much smaller amounts than the better-known metabolite 3,4,5-trimethoxyphenylacetic acid. The finding suggests that the body processes mescaline through an additional, minor chemical pathway that produces an anionic compound, though its overall role in mescaline metabolism is limited.
Study at a glance
| Characteristics | Observational study Peer reviewed |
|---|---|
| Population | Human volunteers |
| Intervention | mescaline sulfate |
| Dose | 400 mg |
| Topics | Mescaline |
| Keywords | Metabolite Urine Chemistry Chromatography |
| Citations | 14 |
| Key finding | After ingestion of 400 mg of mescaline sulfate, the metabolite 3,4,5-trimethoxybenzoic acid was isolated from urine in very low amounts compared to 3,4,5-trimethoxyphenylacetic acid. |
Abstract
After ingestion of 400 mg of mescaline sulfate by human volunteers, 3,4,5-trimethoxybenzoic acid was isolated from urine and identified by gas chromatography-mass spectrometry. The amount of this anionic mescaline metabolite was found to be very low as compared with that of the well-konwn 3,4,5-trimethoxyphenylacetic acid. The significance of this finding is discussed.