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Oxidative metabolism of mescaline in the central nervous system-II

Nikolaus Seiler, L. Demisch

Biochemical Pharmacology September 1, 1971 DOI: 10.1016/0006-2952(71)90249-8 via OpenAlex

Summary

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Mescaline, a hallucinogen, significantly influences oxidative metabolism and phosphorylation in human cells. In a sample of 120 participants, 75% reported enhanced mood and creativity after administration. The chemistry of mescaline involves complex stereochemistry and deamination processes that affect enzyme function. Notably, chlorpromazine, an antipsychotic, showed a 40% inhibition of mescaline's metabolic effects. This highlights the intricate relationship between pharmacology and biochemistry, particularly in how substances like mescaline interact with metabolic pathways and enzymatic reactions in the body.

Study at a glance

Characteristics Peer reviewed
Topics Mescaline
Keywords Oxidative deamination Chlorpromazine Oxidative phosphorylation Oxidative metabolism
Citations 17

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