PRECLINICAL STUDY: Acquisition and reinstatement of MDMA‐induced conditioned place preference in mice pre‐treated with MDMA or cocaine during adolescence
Manuel Daza‐losada, Marta Rodríguez‐arias, María A. Aguilar, José Miñarro
Addiction Biology September 8, 2009 DOI: 10.1111/j.1369-1600.2009.00173.x via OpenAlex
Summary
AI-generated from the abstractAdolescent mice exposed to MDMA, cocaine, or both drugs showed lasting changes into adulthood in their response to MDMA. Only those pre-treated with MDMA alone developed a conditioned place preference for a low dose of MDMA. All groups developed preference for a higher dose, but extinction took longer in mice pre-treated with cocaine (46 sessions) or MDMA alone (28 sessions). Preference was reinstated with progressively lower priming doses in mice pre-treated with MDMA or cocaine alone. Early exposure to MDMA or cocaine induces long-lasting changes that modify adult responses to MDMA.
Study at a glance
| Characteristics | Animal experiment Peer reviewed |
|---|---|
| Population | Adolescent mice |
| Interventions | MDMA cocaine |
| Dose | 10 mg/kg MDMA, 25 mg/kg cocaine, 10 mg/kg MDMA plus 25 mg/kg cocaine |
| Duration | 3-day pre-treatment (PD28-30), conditioned place preference procedure initiated at PD52 |
| Citations | 37 |
| Key finding | Adolescent exposure to MDMA or cocaine induces long-lasting changes that alter adult responses to MDMA, including altered conditioned place preference acquisition, extinction, and reinstatement. |
Abstract
ABSTRACT Those who take ecstasy are more likely to consume other drugs than non‐users with cocaine abuse being reported by 75.5% of high school student MDMA (± 3,4‐methylenedioxymetamphetamine hydrochloride) users. The aim of this work was to evaluate the effects of exposure during adolescence to MDMA, cocaine or to both drugs on the MDMA‐induced conditioned place preference (CPP) in adult mice. Animals received two daily administrations of saline, 10 mg/kg of MDMA, 25 mg/kg of cocaine or 10 mg/kg of MDMA plus 25 mg/kg of cocaine over 3 days (from PD28 to 30). Three weeks after pre‐treatment, the MDMA‐induced CPP procedure was initiated (PD52). Acquisition of CPP was induced with a sub‐threshold dose of MDMA (1.25 mg/kg) only in animals treated during adolescence with MDMA alone. Preference was established in all the groups after conditioning with 10 mg/kg of MDMA, while the time required to achieve extinction was longer in those pre‐treated with cocaine or MDMA alone (46 and 28 sessions, respectively). Moreover, preference was reinstated with progressively lower priming doses of MDMA in mice pre‐treated with MDMA or cocaine alone. These results demonstrate that early exposure to MDMA or cocaine induces long‐lasting changes that last until adulthood and modify the response of animals to MDMA.