A three-choice discrimination procedure dissociates the discriminative stimulus effects of d-amphetamine and (±)-MDMA in rats.
Experimental and Clinical Psychopharmacology January 1, 2000 DOI: 10.1037//1064-1297.8.3.415 via OpenAlex
Summary
AI-generated from the abstractMDMA produces subjective effects in humans that are similar to, but distinguishable from, those of psychostimulants. In rats trained to discriminate between MDMA and d-amphetamine using a three-choice operant procedure, cocaine fully substituted for d-amphetamine, while LSD dose-dependently increased MDMA-appropriate responding, reaching nearly complete substitution (78%) for MDMA. The hallucinogen 2,5-dimethoxy-4-bromoamphetamine only partially substituted for MDMA and severely disrupted response rate. Fenfluramine and both isomers of MDA fully substituted for MDMA. The serotonin-receptor antagonist pirenpirone only partially blocked MDMA discrimination.
Study at a glance
| Characteristics | Drug discrimination study Peer reviewed |
|---|---|
| Population | Rats |
| Interventions | MDMA d-amphetamine cocaine LSD 2 5-dimethoxy-4-bromoamphetamine fenfluramine MDA pirenpirone |
| Topics | MDMA Serotonin |
| Keywords | Hallucinogen Fenfluramine Stimulant Dextroamphetamine |
| Citations | 44 |
| Key finding | MDMA and d-amphetamine can be established as discriminative stimuli in rats using a three-choice operant procedure, with fenfluramine and both isomers of MDA fully substituting for MDMA, while LSD nearly completely substituted for MDMA and cocaine fully substituted for d-amphetamine. |
Abstract
(+/-)-3,4-Methylenedioxymethamphetamine (MDMA) produces subjective effects in humans that are similar to, but distinguishable from, those of psychostimulants. Drug discrimination studies in nonhumans have yielded inconsistent results regarding the similarities between MDMA and the psychomotor stimulant d-amphetamine. This study successfully used a 3-choice operant procedure to establish MDMA and d-amphetamine as discriminative stimuli in rats. Cocaine produced complete substitution for d-amphetamine, and LSD produced dose-dependent increases in MDMA-appropriate responding with nearly complete substitution (78%) for MDMA. The hallucinogen 2,5-dimethoxy-4-bromoamphetamine only partially substituted for MDMA and severely disrupted response rate. Fenfluramine and both isomers of 3,4-methylenedioxyamphetamine (MDA) all produced complete substitution for MDMA. The serotonin-receptor antagonist pirenpirone only partially blocked MDMA discrimination.