Cortical Serotonin Transporter Density and Verbal Memory in Individuals Who Stopped Using 3,4-Methylenedioxymethamphetamine (MDMA or "Ecstasy")
Liesbeth Reneman, Jules Lavalaye, Ben Schmand, Frederik A. de Wolff, Wim van den Brink, Gerard J. den Heeten, Jan Booij
Archives of General Psychiatry October 1, 2001 DOI: 10.1001/archpsyc.58.10.901 via OpenAlex
Summary
AI-generated from the abstractMDMA may cause lasting memory problems even after its toxic effects on serotonin neurons in the brain's cortex reverse. The study suggests that damage to memory function from MDMA use can persist over the long term, while the neurotoxic effects on serotonin-producing neurons might be reversible.
Study at a glance
| Characteristics | Empirical study Peer reviewed |
|---|---|
| Intervention | MDMA |
| Topics | MDMA Serotonin |
| Keywords | Serotonin transporter Psychology Recall |
| Citations | 192 |
| Key finding | MDMA's effects on memory function may be long-lasting, even though its neurotoxic effects on serotonin neurons in the human cortex may be reversible. |
Abstract
The present study suggests that, while the neurotoxic effects of MDMA on 5-HT neurons in the human cortex may be reversible, the effects of MDMA on memory function may be long-lasting.