Presence and evolution of a new psychoactive tryptamines branch
Á. Palma Conesa, L. Galindo Guarín, M. Grifell Guàrdia, P. Quintana Mathe, Cristina Gil, I. Fornís Espinosa, M. Ventura Vilamala, Marta Torrens, Magı́ Farré Albaladejo, M.f. Fonseca Casals
European Psychiatry March 1, 2016 DOI: 10.1016/j.eurpsy.2016.01.131 via OpenAlex
Summary
AI-generated from the abstractFrom 2009 to 2014, a Spanish harm reduction service analyzed over 17,000 drug samples and found the new psychoactive tryptamines 4-HO-DiPT and 4-AcO-DiPT in 16 samples each, and DiPT in only 4. Nine samples contained both 4-HO-DiPT and 4-AcO-DiPT. Deliveries of 4-HO-DiPT increased over the study period (4 samples in 2014), while those of 4-AcO-DiPT and DiPT decreased (1 sample each in 2014). This trend suggests a progressive replacement of 4-AcO-DiPT and DiPT by 4-HO-DiPT for recreational use. Clinical concern arises from the growing use and lack of scientific evidence on humans, with effects predicted only from users' subjective experiences.
Study at a glance
| Characteristics | Observational study Peer reviewed |
|---|---|
| Sample size | 17,432 |
| Population | Samples delivered to Spanish harm reduction service Energy Control |
| Duration | 2009 to 2014 |
| Keywords | Chemistry |
| Key finding | 4-HO-DiPT presence increased from 2009 to 2014 while 4-AcO-DiPT and DiPT decreased, suggesting a replacement in recreational use. |
Abstract
Introduction New psychoactive substances (NPS) are substances that have recently appeared on the market and are not under international control. NPS use is experiencing an unprecedented increase. DiPT, 4-HO-DiPT and 4-AcO-DiPT are new psychoactive tryptamines and their effects may differ from those of other psychoactive tryptamines. Objective To explore the presence of DiPT, 4-HO-DiPT and 4-AcO-DiPT from samples delivered to and analyzed by Spanish harm reduction service Energy Control. Materials and methods All samples analyzed from 2009 to 2014 delivered as DiPT, 4-HO-DiPT and 4-AcO-DPT or containing these substances. Analysis was performed by gas chromatography–mass spectrometry. Results From 17,432 samples, 4-HO-DiPT was found in 16, delivered as 4-HO-DiPT (6); 4-AcO-DiPT (7); DiPT (1); 4-AcO-DMT (1) and cocaine (1). 4-AcO-DiPT was found in 16, delivered as 4-AcO-DiPT (12); 5-MeO-DMT (1); 5-MeO-DiPT (1); 4-AcO-DMT (1) and cocaine (1). Only 4 samples contained DiPT, all presented as DiPT. Nine samples contained both 4-AcO-DiPT and 4-HO-DiPT. During the years of study, 4-HO-DiPT deliverance was increasing (4 samples in 2014) while deliverance of 4-AcO-DiPT and DiPT was decreasing (1 sample in 2014). Conclusions Increasing 4-HO-DiPT presence could translate a progressive replacement of 4-AcO-DiPT and DiPT recreational use. Clinical relevance comes from its growing use and the absence of scientific evidence on humans, therefore relying on users subjective experience to predict the effects. Disclosure of interest The authors declare that they have no competing interest.