The intracranial injection of drugs in goldfish. I: Hallucinogens and their antagonism to smooth muscle activity
Harold A. Abramson, H. H. Gettner, P. A. Carone, Anabela P. Rolo, Leonard W. Krinsky
Journal of Asthma Research January 1, 1979 DOI: 10.3109/02770907909106614 via OpenAlex
Summary
AI-generated from the abstractA simplified method for studying the surfacing reaction of goldfish to hallucinogens uses intracranial injection in fish weighing up to three grams. The drugs d-lysergic acid diethylamide (LSD-25), d-2-acetyl lysergic acid diethylamide (ALD-52), 1-methyl d-lysergic acid butanolamide (UML-491), and 5-methoxy dimethyl tryptamine (5-MEO-DMT) were as pharmacologically active as previously noted in fish and in humans. The relationship of these drugs to their anti-serotonin activity is of particular interest to allergists because the congeners and derivatives of LSD block the action of serotonin on smooth muscle.
Study at a glance
| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Goldfish weighing up to three grams |
| Interventions | d-2-acetyl lysergic acid diethylamide (ALD-52) 1-methyl d-lysergic acid butano-lamide (UML-491) and 5-methoxy dimethyl tryptamine (5-MEO-DMT) |
| Topics | LSD Serotonin |
| Keywords | Tryptamine Hallucinogen Pharmacology |
| Citations | 4 |
| Key finding | D-lysergic acid diethylamide (LSD-25), d-2-acetyl lysergic acid diethylamide (ALD-52), 1-methyl d-lysergic acid butanolamide (UML-491), and 5-methoxy dimethyl tryptamine (5-MEO-DMT) were as pharmacologically active in goldfish as previously noted in fish and in humans. |
Abstract
A simplified method of studying the surfacing reaction of goldfish to hallucinogens is described. Goldfish weighing up to three grams are injected intracranially. Employing this method, d-lysergic acid diethylamide (LSD-25), d-2-acetyl lysergic acid diethylamide (ALD-52), 1-methyl d-lysergic acid butano-lamide (UML-491), and 5-methoxy dimethyl tryptamine (5-MEO-DMT) were found to be as pharmacologically active as previously noted in fish and in man. The relationship of these drugs to their anti-serotonin activity is of particular interest to the allergist because of the way in which the congeners and derivatives of LSD block the action of serotonin on smooth muscle.