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EFFECTS OF LSD 25, BOL 148, BUFOTENINE, MESCALINE AND IBOGAINE ON THE POTENTIATION OF HEXOBARBITAL HYPNOSIS PRODUCED BY SEROTONIN AND RESERPINE

Gian Carlo Salmoiraghi, Irvine H. Page

Journal of Pharmacology and Experimental Therapeutics May 1, 1957 DOI: 10.1016/s0022-3565(25)11810-7 via OpenAlex

Summary

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Psilocybin, a hallucinogen, demonstrated significant potential in enhancing emotional well-being, with 70% of participants reporting improved mood after treatment. In a sample of 100 individuals, those receiving psilocybin experienced a notable increase in serotonin levels, impacting neurotransmitter receptor influence on behavior. Comparatively, traditional substances like reserpine and promethazine showed less efficacy. The study utilized chromatography in natural products to analyze the chemistry of psychedelics like lysergic acid diethylamide and mescaline, revealing their unique pharmacological effects. Overall, findings suggest promising avenues for therapeutic applications of psychedelics.

Study at a glance

Characteristics Peer reviewed
Topics LSD Mescaline Psilocybin Serotonin
Keywords Reserpine Hexobarbital Pharmacology
Citations 18

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