LSD produces place preference and flavor avoidance but does not produce flavor aversion in rats.
Behavioral Neuroscience January 1, 1996 DOI: 10.1037//0735-7044.110.3.503 via OpenAlex
Summary
AI-generated from the abstractLysergic acid diethylamide (LSD) produces a conditioned place preference only at the highest dose tested (0.2 mg/kg), and this preference is prevented by a single preexposure to the conditioning chamber (latent inhibition). When paired with sucrose, LSD doses from 0.05 to 0.2 mg/kg produce taste avoidance, but no dose produces an aversion to the taste as measured by the taste reactivity test. These results indicate that LSD, like other rewarding drugs, causes taste avoidance through a mechanism different from that of emetic drugs.
Study at a glance
| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Rats (implied by typical place conditioning and taste reactivity paradigms) |
| Intervention | Lysergic acid diethylamide (LSD) |
| Dose | 0.05 to 0.2 mg/kg |
| Topics | Addiction LSD Serotonin |
| Keywords | Conditioning Flavor Taste aversion Conditioned place preference Preference test |
| Citations | 41 |
| Key finding | LSD produces conditioned place preference only at the highest dose (0.2 mg/kg) and induces taste avoidance without producing taste aversion, suggesting a mechanism distinct from emetic drugs. |
Abstract
The hedonic properties of lysergic acid diethylamide (LSD) were assessed using the place conditioning, taste reactivity, and taste avoidance tests. LSD produced a conditioned place preference, but only at the highest dose tested (0.2 mg/kg). A single preexposure to the conditioning chamber (latent inhibition) prevented the establishment of a place preference. When paired with sucrose, doses of 0.05 to 0.2 mg/kg of LSD produced taste avoidance, but no dose of LSD produced an aversion to the taste as assessed by the taste reactivity test. These results suggest that LSD, like other rewarding drugs, produces taste avoidance by a mechanism other than that produced by emetic drugs.