EFFECTS OF MESCALINE AND LYSERGIC ACID (d-LSD-25)
Paul H. Hoch, James P. Cattell, Harry H. Pennes
American Journal of Psychiatry February 1, 1952 DOI: 10.1176/ajp.108.8.579 via OpenAlex
Summary
AI-generated from the abstractIn schizophrenic patients, mescaline and lysergic acid worsen mental symptoms and produce physiological changes. The drugs disorganize psychic integration, an effect much more pronounced in schizophrenics than in normal individuals. The text discusses potential diagnostic, prognostic, and therapeutic uses of these drugs.
Study at a glance
| Characteristics | Observational study Peer reviewed |
|---|---|
| Population | Schizophrenic patients and normal individuals |
| Interventions | Mescaline Lysergic acid |
| Topics | LSD Mescaline Psilocybin |
| Keywords | Hallucinogen Psychology |
| Citations | 116 |
| Key finding | Mescaline and lysergic acid markedly aggravate mental symptomatology in schizophrenic patients and disorganize psychic integration more than in normals. |
Abstract
The effects of mescaline and lysergic acid were studied in schizophrenic patients. It was found that physiological changes were produced in these patients and that their mental symptomatology was markedly aggravated. The observations made with the above-mentioned drugs on normal individuals were compared with those seen in schizophrenic patients. Mescaline and lysergic acid are drugs that disorganize the psychic integration of a person. This disorganization is much more apparent in schizophrenics than in normals. The diagnostic, prognostic, and therapeutic use of these drugs is also discussed.