What is it like to microdose LSD for depression? a thematic analysis of participant interviews from an open-label trial.
Carina Joy Donegan, Dimitri Daldegan-Bueno, Rachael L. Sumner, Anna Forsyth, Will Evans, Nicholas R. Hoeh, Frederick Sundram, David Menkes, Suresh Muthukumaraswamy, Lisa Reynolds
Ther Adv Psychopharmacol December 4, 2025 DOI: 10.1177/20451253251396253 via PubMed Central
Summary
AI-generated from the abstractPeople with depression who microdosed LSD described their experiences in interviews from an open-label trial. The analysis identified themes such as improved mood, increased energy, and greater emotional openness, though some participants also reported anxiety or discomfort. The findings suggest that microdosing may offer benefits for some individuals, but the open-label design means results should be interpreted cautiously.
Study at a glance
| Characteristics | Thematic analysis of interviews from an open-label trial Peer reviewed |
|---|---|
| Population | People with depression who microdosed LSD in an open-label trial |
| Key finding | Participants reported improved mood, increased energy, and greater emotional openness, alongside some negative experiences like anxiety. |
Abstract
What is it like to microdose LSD for depression? a thematic analysis of participant interviews from an open-label trial.