A randomised placebo-controlled study of the effects of lysergic acid diethylamide microdosing (15 μg) on pain perception in healthy volunteers.
Mauro Cavarra, Nadia R. P. W. Hutten, Jan Schepers, Natasha L. Mason, Eef L. Theunissen, Matthias E. Liechti, Kim P. C. Kuypers, Valerie Bonnelle, Amanda Feilding, Johannes G. Ramaekers
Br J Pain September 4, 2025 DOI: 10.1177/20494637251371626 via PubMed Central
Summary
AI-generated from the abstractA single 15 μg dose of lysergic acid diethylamide (LSD) did not significantly alter pain perception in healthy volunteers compared to placebo in a randomized controlled trial. The study used a double-blind design to test whether a microdose of LSD would produce analgesic effects, but found no meaningful difference between the LSD and placebo conditions on measures of pain tolerance or threshold.
Study at a glance
| Characteristics | Randomized controlled trial Placebo-controlled Peer reviewed |
|---|---|
| Population | Healthy volunteers |
| Dose | 15 μg |
| Key finding | A 15 μg microdose of LSD did not significantly affect pain perception in healthy volunteers compared to placebo. |
Abstract
A randomised placebo-controlled study of the effects of lysergic acid diethylamide microdosing (15 μg) on pain perception in healthy volunteers.