Ketamine Psychedelic Psychotherapy: Focus on its Pharmacology, Phenomenology, and Clinical Applications

Ketamine psychedelic psychotherapy (KPP) is a treatment approach that combines the dissociative anesthetic ketamine with psychotherapy. Ketamine produces a range of effects including analgesic, sedative, anxiolytic, antidepressant, and hallucinogenic properties. The paper reviews clinical applications of KPP, offers practical guidance, and examines the pharmacology and phenomenology of ketamine-induced experiences, including their potential for transpersonal healing and risks of misuse. It aims to serve as an authoritative resource for psychiatrists and others interested in understanding and applying KPP.

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Abstract

Meant to be an authoritative guide for psychiatrists and others interested in understanding and applying ketamine psychedelic psychotherapy (KPP), this paper focuses on its pharmacology, phenomenology, and clinical applications. Ketamine is a dissociative anesthetic widely used by physicians and veterinarians in the United States. In addition to its anesthetic and dissociative properties, ketamine also has a multitude of other psychological and pharmacological properties, which include analgesic, sedative, neuroprotective, anxiolytic, antidepressant, stimulant, euphoriant, and hallucinogenic effects. The literature on the clinical application of KPP is comprehensively reviewed, practical advice for using KPP is given, and the pharmacology and phenomenology of ketamine-induced psychedelic experiences are explored, including in relationship to transpersonal healing and possible iatrogenic consequences of misuse of KPP.