Serotonin 5- Receptor Function as a Contributing Factor to Both Neuropsychiatric and Cardiovascular Diseases

High comorbidity between neuropsychiatric and cardiovascular disorders may be partly explained by the serotonin system, specifically the 5-HT2A receptor. In the brain, this receptor modulates cognition, working memory, and is implicated in schizophrenia and the effects of hallucinogenic drugs. In the periphery, it contributes to vasoconstriction, hypertension, and inflammatory processes that can lead to atherosclerosis. The hypothesis suggests this receptor is a common contributing factor underlying aspects of the comorbidity.

Study at a glance

Abstract

There are high levels of comorbidity between neuropsychiatric and cardiovascular disorders. A key molecule central to both cognitive and cardiovascular function is the molecule serotonin. In the brain, serotonin modulates neuronal activity and is actively involved in mediating many cognitive functions and behaviors. In the periphery, serotonin is involved in vasoconstriction, inflammation, and cell growth, among other processes. It is hypothesized that one component of the serotonin system, the receptor, is a common and contributing factor underlying aspects of the comorbidity between neuropsychiatric and cardiovascular disorders. Within the brain this receptor participates in processes such as cognition and working memory, been implicated in effective disorders such as schizophrenia, and mediate the primary effects of hallucinogenic drugs. In the periphery, receptors have been linked to vasoconstriction and hypertension, and to inflammatory processes that can lead to atherosclerosis.