Neuroscience: Special K gets an 'A'.
Jovin R Jacobs, Adam D Douglass
Current biology : CB April 21, 2025 DOI: 10.1016/j.cub.2025.03.006 via PubMed
Summary
AI-generated from the abstractA tendency to become passive when facing overwhelming challenges is a hallmark of depression. In a zebrafish model of this phenomenon, the antidepressant ketamine promotes long-term improvements in behavioral persistence through a newly discovered mechanism.
Study at a glance
| Characteristics | Animal study Peer reviewed |
|---|---|
| Population | Zebrafish |
| Intervention | Ketamine |
| Keywords | Neuroscience Mental health Antidepressants Behavioral research Pharmacology |
| Key finding | Ketamine promotes long-term improvements in behavioral persistence in a zebrafish model of depression through a novel mechanism. |
Abstract
A hallmark of depression is a tendency to become passive when faced with overwhelming challenges. A recent study models this phenomenon in zebrafish and discovers a novel mechanism by which the antidepressant drug ketamine promotes long-term improvements in behavioral persistence.