Acute Effects of Psilocybin and Salvinorin-A on Functional Connectivity
Frederick A. Bagdasarian, Hanne D. Hansen, Chi‐hyeon Yoo, Michael S. Placzek, Jacob M. Hooker, Hsiao‐ying Wey
Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition August 14, 2024 DOI: 10.58530/2023/3494 via OpenAlex
Summary
AI-generated from the abstractPsilocybin, a serotonergic agonist, and Salvinorin-A, a kappa-opioid receptor agonist, both alter functional connectivity in the brains of non-human primates, but their effects overlap and differ in specific regions. Using fMRI, the study examined how these psychedelics influence connections within the default mode network and the claustrum. The findings suggest that each substance targets distinct receptor systems, leading to both shared and unique patterns of brain network activity, which may help explain their different mechanisms of action.
Study at a glance
| Characteristics | Observational cohort Peer reviewed |
|---|---|
| Population | Non-human primates |
| Interventions | Psilocybin Salvinorin-A |
| Topics | Default mode network Psilocybin Serotonin |
| Keywords | Hallucinogen Claustrum Neuroscience Κ-opioid receptor |
| Key finding | Psilocybin and Salvinorin-A produce overlapping and differing effects on functional connectivity within the default mode network and claustrum. |
Abstract
This work utilized fMRI to assess the influence of the psychedelics, Psilocybin, a serotonergic agonist, and Salvinorin-A, a kappa-opioid receptor (KOR) agonist, on functional connectivity (FC) in non-human primates. We used a seed-based FC analysis, probing regions of interest associated with psychedelic hallucinogens. Our findings highlight the overlapping and differing influence of these substances on FC relative to the subcomponents of the default mode network and the claustrum. This work may provide insight on the mechanisms of action of psychedelics that target differing receptor systems. Key Words: Functional connectivity; Claustrum; DMN; Psychedelics.