Overview Of Review (OoR) on PSILOCYBIN in Psychiatric Disorders

This protocol describes an upcoming overview of reviews that will analyze existing systematic reviews and meta-analyses of randomized clinical trials on psilocybin therapy. The goal is to evaluate the therapeutic effects, safety profiles, and adverse effects of psilocybin across various psychiatric conditions diagnosed according to ICD-10 or DSM-5-TR criteria. The study will compare psilocybin therapy against placebo, no treatment, or standard drug therapies. The authors note the need to consolidate scattered evidence from the growing body of psilocybin research, which could inform future clinical applications and policy.

Study at a glance

Abstract

eview question / Objective This protocol outlines the methodology for an "Overview of Review" (OoR) study which aims to conduct a comprehensive analysis of systematic reviews with meta-analyses of psilocybin randomized clinical trials.The primary objective is to provide an evaluation of the therapeutic effects, safety profiles, and adverse effects of psilocybin as documented in the best evidence available.: P (Population): Patients included in systematic reviews who have undergone psilocybin therapy for various clinical indications (DSM-5-TR or ICD-10 Disorders) **I (Intervention)**: Psilocybin therapy.C (Comparison): placebo, no treatment, or other standard drug or no drug therapies O (Outcomes): 1. Therapeutic effects of psilocybin (efficacy).2. Acceptability and tolerability of psilocybin therapy 3. Prevalence and severity of adverse effects associated with psilocybin therapy (safety profile). RationaleThe motivation for this study arises from the recent surge in interest in psilocybin therapy and the need to consolidate the growing body of findings, which at the moment constitute scattered evidence.Psilocybin, a naturally occurring psychedelic compound found in certain species of mushrooms, has garnered significant scientific and therapeutic interest in recent years.Given the p o t e n t i a l s i g n i fi c a n c e o f p s i l o c y b i n i n revolutionizing mental health treatment and our understanding of consciousness, along with the rapidly evolving research landscape, this overview of reviews is timely and crucial.It aims to provide a comprehensive, evidence-based assessment of the current state of psilocybin research, which could inform future clinical applications, research directions, and policy decisions.Condition being studied Psilocybin therapy in subjects diagnosed with psychiatric disorders according to international diagnostic criteria such as the ICD-10 and DSM-5-TR.