EFFECTS OF PSYCHOTROPIC DRUGS UPON THE EYE MOVEMENTS WITH CLOSED EYES
Y Shimazono, Katsumi Ando, Takashi Tanaka, Minoru Hayashi, Sayuri Sakamoto, Tomoya Eguchi, Hiroyuki Nakamura, Hiroyuki Kamiya
Psychiatry and Clinical Neurosciences June 1, 1967 DOI: 10.1111/j.1440-1819.1967.tb00080.x via OpenAlex
Summary
AI-generated from the abstractIn 45 normal subjects, horizontal eye movements changed after psychotropic drugs. Amobarbital and chlorpromazine gradually eliminated rapid eye movements. LSD-25 increased rapid movements in 80% of subjects and produced large, slow pendular movements in about half, especially among those showing euphoria, disinhibition, and ecstasy. Psilocybin caused similar pendular movements but with longer duration. Methamphetamine and epinephrine initially decreased slow movements and increased rapid ones; epinephrine later transiently increased slow movements. The findings suggest different drugs distinctly alter eye movement patterns, possibly reflecting their mechanisms of action.
Study at a glance
| Characteristics | Experimental study Peer reviewed |
|---|---|
| Sample size | 45 |
| Population | Normal subjects |
| Interventions | Amobarbital Chlorpromazine LSD 25 Psilocybin Methamphetamine Epinephrine |
| Dose | 250 mg, i.v. for amobarbital; 1.0 mg/kg, i.m. for chlorpromazine; 0.5 or 1.0 γ/kg, i.m. for LSD 25; 3 mg, i.m. for psilocybin; 9 mg, s.c. for methamphetamine; 0.005–0.01 mg/kg, s.c. for epinephrine |
| Topics | Psilocybin |
| Keywords | Psychology Chlorpromazine Euphoriant Methamphetamine |
| Citations | 4 |
| Key finding | LSD-25 and psilocybin produce large, slow pendular eye movements, especially in euphoric subjects, while amobarbital and chlorpromazine eliminate rapid eye movements. |
Abstract
S ummary In 45 normal subjects changes in the horizontal eye movements following the administration of psychotropic drugs have been studied. 1. Following the administration of amobarbital (250 mg, i.v.) and chlorpromazine (1.0mg/kg, i.m.), rapid eye movements (R) decreased gradually until they disappeared altogether. 2. LSD 25 (0.5 or 1.0γ/kg, i.m.) produced increase of R in 80% and markedly increased incidence and amplitude of slow movements (S) in about a half of the subjects. These large, slow pendular movements appeared fairly continuously and rhythmically in the subjects exhibiting mainly euphoria, disinhibition and ecstasy. 3. Following the administration of psilocybin (3mg, i.m.), similar pendular movements could also appear, but the duration of each slow movement tended to be longer. 4. Methamphetamine (9mg, s.c.) and epinephrine (0.005–0.01 mg/kg, s.c.) decreased S and increased R, but later than 20 minutes after the injection of epinephrine S appeared transiently. 5. The mechanism of action of the substances on the development of the different groups of the eye movements were discussed on the basis of these data. LSD 25 and psilocybin offered by Sandoz Pharmaceuticals Co., Ltd. were used in the above studies.