Effects ofPsilocybe argentipeson Marble-Burying Behavior in Mice
Yoshihiro Matsushima, Osamu Shirota, Ruri Kikura‐hanajiri, Yukihiro Goda, Fumio Eguchi
Bioscience Biotechnology and Biochemistry August 23, 2009 DOI: 10.1271/bbb.90095 via OpenAlex
Summary
AI-generated from the abstractA hallucinogenic mushroom, Psilocybe argentipes, reduced marble-burying behavior in mice, a model for obsessive-compulsive disorder, without affecting their general movement. The same dose of authentic psilocybin also inhibited burying, but P. argentipes was more effective. These results suggest the mushroom could be useful in clinical therapy for obsessive-compulsive disorder.
Study at a glance
| Characteristics | Animal study Peer reviewed |
|---|---|
| Population | Mice |
| Interventions | Psilocybe argentipes psilocybin |
| Topics | Psilocybin |
| Keywords | Obsessive compulsive Animal model Hallucinogen Pharmacology |
| Citations | 77 |
| Key finding | Psilocybe argentipes significantly inhibited marble-burying behavior without affecting locomotor activity, suggesting potential efficacy in obsessive-compulsive disorder therapy. |
Abstract
Psilocybe argentipes is a hallucinogenic mushroom. The present study examined the effects of P. argentipes on marble-burying behavior, which is considered an animal model of obsessive-compulsive disorder. P. argentipes significantly inhibited marble-burying behavior without affecting locomotor activity as compared with the same dose of authentic psilocybin. These findings suggest that P. argentipes would be efficient in clinical obsessive-compulsive disorder therapy.